Download Qualitätssicherung von Mineralwasser. Methodenvalidierung by Benedikt Werner PDF

By Benedikt Werner

Bachelorarbeit aus dem Jahr 2014 im Fachbereich Chemie - Analytische Chemie, notice: 1,0, Fachhochschule Trier - Hochschule für Wirtschaft, Technik und Gestaltung (angefertigt bei: "Gerolsteiner Brunnen GmbH"), Sprache: Deutsch, summary: Die vorliegende Abschlussarbeit wurde in der Abteilung „Qualitätssicherung“ angefertigt (genauer: im Qualitätssicherungslabor). Die Qualitätssicherung in der Industrie ist von großem Interesse, da hiermit zwei zentrale Fragen des Verbrauchers beantwortet werden: Zum einen wird geklärt, welche Zusammensetzung /Beschaffenheit das angebotene Produkt hat, zum anderen ist die Chargenrückverfolgbarkeit gesichert, falls fehlerhafte Produkte auf den Markt gebracht werden. Der Verkauf von gefährlichen Produkten an den Endverbraucher kann im Optimalfall in a hundred % der Fälle verhindert werden. Ein funktionierendes Qualitätsmanagement hat eine Schlüsselfunktion, wenn es darum geht, eine gleich bleibende, gute Qualität der Produkte sicherzustellen. Es ist wichtig, die notwendigen Arbeitsanweisungen, assessments und Analysen zu bewerten, sei es im hard work oder in der Produktion. Eine systematische Dokumentation aller genannten Aufgaben, der gefundenen Messergebnisse und deren Offenlegung ist zwingend erforderlich [Wrede et. al (2008)].

In dieser Bachelorarbeit sollen zwei Methoden validiert werden. Aussagen zu der Methode in Bezug auf deren Robustheit, Linearität, Messpräzision, Wiederholpräzision, Gesamtpräzision, zeitlicher developments, Spezifität und Wiederfindung sollen gemacht werden. Ursächlich ist, dass zunehmend die Kunden der „Gerolsteiner Brunnen GmbH und Co. KG“ Wert auf eine Methode mit verifizierten Ergebnissen legen. Nach „DIN EN ISO 17025“ soll das Unternehmen nachweisen, dass die bestimmten Messwerte ausreichend genau sind. Eine Validierung der Methoden des Qualitätssicherungslabors wurde für die Produkte der „Gerolsteiner Brunnen GmbH und Co. KG“ noch nicht durchgeführt. Darin besteht jetzt die Aufgabe dieser Bachelorarbeit. Im Zuge der Validierung werden durch die „DIN EN ISO 17025“ die Forderungen an die Labore gestellt:
- Das Laboratorium muss Angaben dazu machen wie hoch die Messschwankungen sind, die sich auf ein durchzu-
führende Kalibrierung auswirken können.
- Verfahren, die das Laboratorium entwickelt oder übernommen hat, dürfen verwendet werden, wenn sie für die
vorgesehene Anwendung geeignet sind und validiert wurden.“
- Prüflaboratorien müssen über Verfahren zur Schätzung der Messunsicherheit verfügen und diese anwenden. Bei
der Schätzung dieser Schwankungen müssen alle Einflussfaktoren mitberücksichtig werden.
- Die Validierung muss geeignet sein. Dies ist zu erfassen.

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Download Advances in Mass Spectrometry: Proceedings of a Conference by R. M. Elliott PDF

By R. M. Elliott

Advances in Mass Spectrometry, quantity 2 records the court cases of a convention on mass spectrometry held in Oxford in September 1961.
This compilation is labeled into six significant themes — mass spectrometry in examine; mass spectrometry of inorganic compounds; tools and strategies; concept and correlation of mass spectra; mass spectra and research; and ionization and dissociation. less than those significant themes, elements of the papers mentioned comprise box ionization mass spectroscopy; preliminary kinetic strength discrimination results in crossed-field ion resources; mass spectrometric research of CaO and Ta; and spark resource mass spectrometry as an analytical procedure. The booklet additionally covers discussions on preliminary power of hydrocarbon fragment ions; decision of the constitution of alkaloids through mass spectrometry; and alertness of a time-of-flight mass spectrometer to the exam of ion-molecule interactions.
This quantity is an invaluable connection with scholars and researchers engaging in paintings on mass spectrometry.

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Download Carbon-13 NMR Spectral Problems (Organic Chemistry) by Robert B. Bates,William A. Beavers PDF

By Robert B. Bates,William A. Beavers

With the appearance of Fourier remodel spectrometers of serious sensitivity, it has turn into functional to acquire carbon-13 nuclear magnetic resonance (C-13 NMR; l3C NMR; CMR) spectra normally on natural molecules, and this method has develop into one of many maximum application in settling on buildings of natural unknowns. while the standard spectrometric recommendations­ proton magnetic resonance (H-I NMR; IH NMR; PMR), infrared (lR), mass (MS), and ultraviolet (UV)-do no longer easily demonstrate a compound's constitution, a C-13 NMR spectrum will usually supply adequate more information to yield it unequivocally. With this in brain, the current paintings used to be designed to offer complex undergraduates, graduate scholars, and training chemists a operating wisdom of and facility with using this important strategy. a few familiarity with different spectrometric options is thought (recommended publication: Silverstein, Bassler, and Morrill, Spectrometric identity of natural Compounds), yet no previous wisdom of C-13 NMR -which is handled very frivolously, if in any respect, within the general simple natural texts-is beneficial. A dialogue of C-13 NMR spectroscopy is by way of one hundred twenty five difficulties, each one along with a molecular formulation, sorts of C-13 NMR spectra (partially and entirely proton decoupled, with connecting strains to facilitate multiplicity assignments), an built-in H-I NMR spectrum, and an important IR, UV, and MS info. those difficulties were very conscientiously ready, completely validated through scholars on the college of Arizona, and we think that only a few mistakes remain.

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Download Laboratory Statistics: Handbook of Formulas and Terms by Anders Kallner PDF

By Anders Kallner

Laboratory facts: guide of formulation and Terms offers universal techniques for evaluating and comparing numerical laboratory information. particularly, the textual content offers with the kind of info and difficulties that laboratory scientists and scholars in analytical chemistry, scientific chemistry, epidemiology, and medical learn face each day. This publication takes the secret out of data and offers uncomplicated, hands-on directions within the layout of daily formulation. so far as attainable, spreadsheet shortcuts and capabilities are integrated, besides many straightforward labored examples. This booklet is a must-have consultant to utilized records within the lab that might lead to more advantageous experimental layout and analysis.

  • Comprehensive assurance of easy statistical strategies familiarizes the reader with formatted statistical expression
  • Simple, labored examples make formulation effortless to exploit in actual life
  • Spreadsheet capabilities exhibit how to define fast ideas to universal problems
  • In-depth indexing and widespread use of synonyms facilitate the fast place of acceptable procedures

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Download Thermal Analysis of Polymers: Fundamentals and Applications by Joseph D. Menczel,R. Bruce Prime PDF

By Joseph D. Menczel,R. Bruce Prime

  • Presents an exceptional creation to thermal research, tools, instrumentation, calibration, and alertness besides the mandatory theoretical background.
  • Useful to chemists, physicists, fabrics scientists, and engineers who're new to thermal research strategies, and to latest clients of thermal research who want extend their adventure to new concepts and applications
  • Topics lined comprise Differential Scanning Calorimetry and Differential Thermal research (DSC/DTA), Thermogravimetry, Thermomechanical research and Dilatometry, Dynamic Mechanical research, Micro-Thermal research, sizzling level Microscopy, and Instrumentation.
  • Written through specialists within the quite a few parts of thermal analysis
  • Relevant and certain experiments and examples stick with each one chapter.

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Download The HPLC Expert: Possibilities and Limitations of Modern by Stavros Kromidas PDF

By Stavros Kromidas

The quick improvement of HPLC instrumentation and know-how opens a number of probabilities - and involves new questions. Which column may still i select to procure top effects, which gradient suits to my analytical challenge, what are contemporary and promising tendencies in detection innovations, what's state-of-the-art concerning LC-MS coupling? some of these questions are replied by way of specialists in ten self-contained chapters. in addition to those extra hardware-related and technical chapters, additional comparable components of curiosity are coated: comparability of contemporary chromatographic facts platforms and integration innovations, clever documentation, effective info seek in net, and assistance for a profitable FDA inspection. This functional method bargains in a condensed demeanour contemporary developments and tricks, and also will show the complicated reader error and error he was once no longer conscious of so far.

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Download Mass Spectrometry Handbook (Wiley Series on Pharmaceutical by Mike S. Lee PDF

By Mike S. Lee

because of its huge, immense sensitivity and straightforwardness of use, mass spectrometry has grown into the analytical software of selection in such a lot industries and parts of study. This distinct reference presents an intensive library of tools utilized in mass spectrometry, protecting functions of mass spectrometry in fields as assorted as drug discovery, environmental technology, forensic technology, medical research, polymers, oil composition, doping, mobile learn, semiconductor, ceramics, metals and alloys, and native land defense. The publication offers the reader with a protocol for the approach defined (including sampling equipment) and explains why to take advantage of a selected process and never others. crucial for MS experts operating in commercial, environmental, and scientific fields.

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Download Topics in Fluorescence Spectroscopy, Vol. 5: Nonlinear and by Joseph R. Lakowicz PDF

By Joseph R. Lakowicz

Fluorescence spectroscopy keeps its boost to extra refined tools and purposes. As one seems to be over the former many years, its appears to be like that the 1st functional tools for time-resolved measurements seemed within the 1970’s. The instrumentation and research tools for time-resolved fluorescence complicated swiftly during the 1980’s. for the reason that 1990 we now have witnessed a swift migration of the foundations of time-resolved fluorescence to cellphone biology and medical appli- tions. such a lot lately, we've seen the advent of multi-photon excitation, pump-probe and prompted emission equipment for reports of organic mac- molecules and for mobile imaging. those complicated subject matters are the topic of the current quantity. Two-photon excitation used to be first expected through Maria Goppert-Mayer in 1931, yet was once no longer experimentally saw till 1961. commentary of two-photon excitation required the advent of lasers which supplied sufficient photon density for multi-photon absorption. because the early observations of two-photon excitation within the Nineteen Sixties, multi-photon spectroscopy has been restricted to a bit of unique purposes of chemical physics, the place it's used to review the digital symmetry of small molecules. putting one’s self again in 1980, it'd be not easy to visualize using multi-photon excitation in biophysics or mobile imaging.

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Download Analysis of Taste and Aroma (Molecular Methods of Plant by John F. Jackson,H.F. Linskens PDF

By John F. Jackson,H.F. Linskens

Molecular equipment of Plant research thought of the sequence The strong recombinant DNA expertise and similar advancements have had a big effect on molecular biology. Any therapy of plant research needs to utilize those new tools. advancements were so quick and the equipment so robust that the editors of contemporary tools of Plant research have now made up our minds to rename the sequence Molecular equipment ofPlant research. this may now not swap the final goals of the sequence, yet most sensible describes the thrust and content material of the sequence as we cross ahead into the recent millennium. this doesn't suggest that each one chapters a priori deal basically with the equipment of molecular biology,but really that those equipment are to be present in many chapters including the extra conventional tools of study that have visible contemporary advances. The numbering of the volumes of the sequence as a result maintains on from 20, that's the main lately released quantity less than the identify glossy tools ofPlant research. As indicated for prior volumes, the the right way to be present in Molecular equipment ofPlantAnalysis are defined critically,with tricks as to their obstacles, references to unique papers and authors being given, and the chapters written in order that there's no need to refer to different texts to hold out the equipment of study defined. All authors were selected due to their certain event in dealing with plant fabric and/or their services with the equipment described.

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